Stories

Effect of Myosin Isoforms from Mouse to HumanTo understand how pathology-induced changes in contractile protein isoforms modulate cardiac muscle function, it is necessary to quantify the temporal-mechanical properties of contractions that occur under various conditions. Pathological responses are much easier to study in animal model...

L48Q and I61QA challenge in experimental studies of muscle diseases is accounting for the effect of variable mutation incorporation into myofilaments. In this study, we used a spatially explicit computational model MUSICO Fiber, informed by experimental data from transgenic mice expressing one of two mutations...

We are excited to announce FilamenTech’s participation in a new scientific project called “Analysis Tools for Fiber Diffraction of Muscle” (R01GM144555), supported by National Institute of General Medical Sciences of the National Institutes of Health. Principal investigator is Thomas C. Irving from Illinois Institute of...

FilamenTech has recently started a collaboration with prof. Aleksandar G. Ostrogorsky from Illinois Institute of Technology, Chicago, IL, USA on performing simulations and data analysis for the optimization of the DiGS experiments conducted on Earth and at the ISS (International Space Station) within the project:...

Over the last 4 years, FilamenTech’s co-founders prof. Srboljub Mijailovich and Momcilo Prodanovic, along with FilamenTech’s scientific board members were involved in the project called “SilicoFCM - In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy” (No 777204),...