Effect of Myosin Isoforms from Mouse to HumanTo understand how pathology-induced changes in contractile protein isoforms modulate cardiac muscle function, it is necessary to quantify the temporal-mechanical properties of contractions that occur under various conditions. Pathological responses are much easier to study in animal model...
L48Q and I61QA challenge in experimental studies of muscle diseases is accounting for the effect of variable mutation incorporation into myofilaments. In this study, we used a spatially explicit computational model MUSICO Fiber, informed by experimental data from transgenic mice expressing one of two mutations...
MavacamtenMavacamten (MYK-461) was recently approved by FDA as an allosteric inhibitor of sarcomeric myosins since it had been successfully used in clinical trials for treatment of obstructive HCM. Mavacamten negative inotropic action is likely mediated by the shift of detached motor heads towards auto inhibited...