Case studies

How does a sarcomere-targeted drug change cardiac function at the whole-heart level? This case study demonstrates how MUSICO simulates the...

Animal models frequently fail to predict human cardiac drug response because myosin isoform composition differs fundamentally between species. This case...

Genetic cardiomyopathies present a fundamental challenge: the same disease category contains patients with distinct molecular dysfunctions that respond differently to...

Synchrotron X-ray fiber diffraction is the most direct experimental window into myosin head states during muscle contraction and drug binding,...

Duchenne muscular dystrophy is caused by absence of dystrophin, the structural protein that transmits contractile forces between sarcomeres and the...

Why does tidal breathing prevent dangerous airway narrowing in healthy lungs, but fail in asthma? The answer lies in the...